Progress and Perspectives on Nanocarrier Mediated Drug Delivery for Brain-Tumor Targeting

Abstract

Brain tumors is one of the most dangerous diseases to be diagnosed and treated, primarily due to the difficulty of crossing the blood-brain barrier to the brain with imaging and therapy agents. Nanoparticles have immense potential as an efficient drug delivery system. In this review, I discussed recent developments in nanotechnology for the delivery of drugs. Throughout recent years, nanotechnology has been involved throughout solving the problems of gene supply and drug supply. Nano systems with various compositions and biological properties have been thoroughly studied for drug and gene delivery applications. In order to ensure an efficient supply of medicines, it is necessary to understand the interactions of nanomaterials with the biological environment, aimed at cell surface receptors, the release of medicines, multiple drug use, the stability of therapeutic agents and the molecular signaling mechanisms of the disease under consideration. Nanomaterials, Quantum dots, chitosan, polylactic/glycolic acid (PLGA), and nanoparticle PLGA have been successfully developed for a variety of anti-carcinogenic drugs including paclitaxel, doxorubicin, 5-fluorouracil, and dexamethasone. The rational development of nano systems on the basis of their understanding of biological environment interactions, cell target population, cell surface target receptors is an effective approach to achieving effective drug delivery.