Expression of IL-1b, IL-12, IL-17a, TNF-a and Fox-P3 in Patients with Low, Medium and High-Hepatitis Viral Load

Abstract

Hepatitis B virus infection(HBVI)  is a major causing of concern world.wide causing significant mortality. Poor diagnosis and prognostic factors remain one of crucial factors responsible for poor management of the disease.  Here in this study we show that the inflammatory cytokine such as IL-1b, IL-17a, TNF-A have a major prognostic value in HBV patients. In addition to these cytokine immune-suppressing FoxP3 can also have a vital implication in the prognosis and overall survival of HBV patients. As such we analyzed the mRNA expression of IL(1b;17a ;12); TNF-A; and FoxP3 in HBV patients with high, medium and LVLpatients. We here found that the expression of IL-1beta and TNF-alpha were high in HVLgroups indicating the high immune response against HBV and similarly suppressive effect by FoxP3 in LVLgroup in response to the overall suppression of inflammation.  Therefore, supplementation of IL-1beta and /or TNF alpha can support clearance of HBV at initial stages of infection but also important here is to monitor the expression of immune suppressinf FoxP3 which may prevent in eliciting a potent immune response against HBV.