Impact of Liver Test Abnormalities and Chronic Liver Disease on the Clinical Outcomes of Patients Hospitalized with COVID-19 in vidharbha region of Central India
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Abstract
INTRODUCTION:
The severe acute respiratory syndrome corona virus 2 (SARS-CoV-2) or novel corona virus disease (COVID-19) pandemic is sweeping the globe. Latest information on the outbreak of the corona virus epidemic in 2019, which was caused by the extreme acute respiratory syndrome corona virus 2 strains, has begun to shed light on the disease's effects on the liver. However, no studies have systematically to date, there have been no impaired liver tests in COVID-19 patients. In patients with irregular liver test results, we looked at the clinical features of COVID-19. The goal of this research was to explain the clinical outcomes of COVID-19 in patients with irregular liver tests and CLD.
AIM:We performed an observational study to see how irregular liver tests and patients' clinical outcomes were influenced by chronic liver disease admitted to SMHRC Nagpur.
MATERIAL AND METHODS:
The research included 200 people aged 25 to 65 years old who had been diagnosed with corona positive and were admitted to Shalinitai Meghe Hospital in Nagpur. They were split up into different parties. One group had chronic liver disease, and the other did not, but both groups had patients that were corona positive. We included patients who had liver defects as a result of corona viruses in this study. During the research phase, we gathered information from this patient. As a research group and a control group, we test SGOT, SGPT, ALP, Protein, Total bilirubin, and GGT levels.
RESULTS:
The findings show that corona positive patients with liver disease had elevated liver function tests, such as increased levels of SGOT, SGPT, Total billirubin, Alkaline phosphates, and GGT, when compared to those who did not have any liver abnormalities but were corona positive. A history of irregular liver tests and liver damage was related to the development of serious pneumonia. The detrimental impacts on liver injury were linked to some drugs taken during hospitalization, implying that these patients should be monitored and evaluated on a regular basis.
CONCLUSION:
Patients who had irregular liver tests were more likely to develop serious disease. The negative effects on liver damage were mostly due to some drugs taken during hospitalization, which should be closely monitored and evaluated.