Study on Activity of Liver Enzymes in HIV affected Women

Abstract

BACKGROUND:HIV is a type of retrovirus that belongs to the well-known lentivirus family and is defined by a long duration of survival and replication prior to disease onset. While all AIDS patients have immunological dysfunction, the clinical continuum of HIV infection is complex, and multiple organ involvement is normal. Liver disease has been linked to HIV infection, and symptoms include unexplained fevers, hepatomegaly, and subclinical irregularities in liver function studies.

OBJECTIVES:To measure SGOT, SGPT, and ALP in HIV/AIDS patients and equate them to healthy people.

MATERIAL AND METHODS:This study was conducted in collaboration with Jawaharlal Nehru Medical College, Sawangi (Meghe), Wardha, Maharashtra, India, in the Department of Biochemistry at Datta Meghe Medical College in Nagpur.Total 40 individuals were included in the study and divided into 2 groups: Group I: HIV positive group and Group II: healthy controls.

RESULTS: Level of SGOT were significantly increased (P=0.005) in HIV positive patients as compare to healthy controls. SGPT level and ALP level were non-significantly increased in the HIV positive patients while comparing them with healthy controls.

CONCLUSIONS:Our results suggest that liver damage in ART-naive HIV-infected women is partially due to HIV infection's symptoms, and that liver diseases are less common in industrialized countries than previously believed. Advanced HIV infection is most likely the cause of impaired liver synthesis.