Correlation between the Bone Disorder and Hemoglobinopathy in Vidarbha Region.

Abstract

INTRODUCTION:

In patients with thalassaemia and other haemoglobin disorders, bone disease is a significant cause of morbidity. The involvement of diabetes and hypothyroidism, parathyroid gland dysfunction, haemolytic anaemia, progressive marrow expansion, iron toxicity on osteoblasts, iron chelators, and a lack of growth hormone or insulin growth factors have all been identified as major causes of osteoporosis in thalassaemia patients. As a result, potent inhibitors of osteoclast activation, such as aminobisphosphonates, become effective drugs for the treatment of osteoporosis in patients with thalassaemia and other haemoglobin disorders.

AIM: We conducted a cross sectional study to inspect the correlation between bone disorder and hemoglobinopathy patients those came in theirregular follow up in SMHRC Nagpur.

MATERIAL AND METHODS:

Total 150 individuals of the age group between 35-80 yrs, the patients was already had hemoglobinopathy and coming for their regular check-up at Shalinitai Meghe hospital Nagpur, was choose for the research. They were split into class. One group having hemoglobinopathy with bone disorder group, another group with hemoglobinopathy not had bone disorder.In this study we include the patients those already suffered from BMD. We collected data from this patient during the research period.We assess the levels of hemoglobin, calcium, phosphorous, and Ferittin in hemoglobinopathy with had bone disorder as study group and other control group.

RESULTS:

According to the findings of this report, osteoporosis is measured using a quantitative evaluation of BMD. There was no difference in BMD between men and women in this sample. Males had slightly higher hemoglobin and hematocrit levels. There was a statistically significant link between lumbar spine and skeletal muscle mass (SMM). Multiple regression analysis indicated that Hb has a 45.1 percent statistical impact on BMD. These results help to explain the relationship between BMD and Hb; a lower Hb level is related to a lower BMD. The highest indicator of abnormal BMD was the Hb stage.

CONCLUSION:

This study showed that a low Hb value wassignificantly correlated with low bone mass, suggesting that a low Hb value is a risk factor forchanges in bone turnover that leads to a decrease bone density.