Electrocardiographic Effect of Hydroxychloroquine on Rabbit's Heart

Abstract

           This study involved evaluation the effects of Hydroxychloroquine administration on the heart that associated with therapeutic dose in the rabbits. The experiment was carried out on twenty rabbit were divided into two groups equally (10 rabbits in each group) which were dosed for four weeks daily as follows: The first group was treated with distilled water as control, the second group was treated with Hydroxychloroquine (400 mg/kg B.wt.) orally. The electrocardiograph results of lead II were referred to the value of R-R was significantly decreased, but the QRS duration was significantly increase. The T duration there was increased significantly, but there were significant decreases in P-R duration, while Q-T duration found that was significant increase. We concluded that Hydroxychloroquine has adverse effect on the rabbit's heart.