Uterine leiomyomas (Uterine fibroids)
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Abstract
Uterine fibroids are neoplasms of the uterus with both smooth muscle and fibroblast constituents, additionally to an amount of fibrous extracellular matrix. Fibroids are completely different in their pathophysiology, size, site and their clinical symptoms. In spite of the fact that uterine leiomyomas represent a significant public health concern, the causes and pathogenesis of these lesions not very well understood. Fibroids are usually associated with race; seen in black women more than in white one with more-severe forms of the disease. Symptomatic fibroids interfere with physical and social activities, affecting relationships, employment and making women feel worn out and sad or depressed. About one- third to half of all hysterectomies are fibroids . Treatments are surgical and interventional. The progesterone receptor modulators, such as ulipristal acetate, are used as a medical therapy. There is a new suggestion that the genetic subgroups lead to fibroid formation, aid in the understanding of the clinical heterogeneity of this disease and lead to individualized treatments. This article will summarize the important information published in recent years about this disease.