Microspheres Preparation of Cefaclor (Solvent Evaporation) and Evaluation

Abstract

     The aim of the present study was to develop and characterize Cefaclor microspheres containing ethyl cellulose as sustained release delivery system. Cefaclor microspheres are prepared by solvent evaporation technique and were found to be intact and spherical shape. Their particle size range was found to be 178.0 to 245.3 µm. Scanning electron microscopy showed spherical shape of microspheres. The loading efficiency showed maximum value when the concentration of Cefaclor and ethyl cellulose was 1:4. Best retardation of Cefaclor release from ethyl cellulose in all formulations were showed, but formulation CF1 is the optimized formulation and the drug release showed 94.71% up to 12 hrs and order of release was zero order, it was best fitted in Korsmeyer Peppas model.