Effects of Lead Toxicity on Renal Biochemical Indices before and after Treatment with Pimpinella Anisum Aqueous Extract

Abstract

• Background: Lead poisoning may induce nephrotoxicity, a result of several renal function disorders in animals and humans. Pimpinella anisum L, thus. The medicinal results and the kidney are more properly understood.


• Aim of the Study: an estimation of the therapeutic effects of anisum L oral administration on rats with lead toxicity.


• Materials and methods:2% of the lead of conception and lactation has been exposed to the young rats. In weaning, aqueous extract P. anisum L was treated orally. Fifteen days (500-750 mg/kg). The evaluation of renal activity was conducted with the calculation of some biochemical indicators, such as creatnine, uric acid, urea such as complete proteins, lipid peroxidation (LPO) and catalase.


• Results: Lead cause elevation of amount of Biochemical markers were observed (Urea, creatinine, acid uric). anisum L oral administration causing decrease in the levels of these parameters in addition to GGT and protein, also the kidney weight was decreased significantly after treatment with P. anisum.