Evaluation of Anti-Obesity Potential of Cappris Spinosa

Abstract

Ischemic heart disease, cancer, and stroke are the leading causes of death worldwide, in recent years. These diseases are related to the “epidemic of obesity,” one of the major global health concerns. Due to high-calorie diet and sedentary lifestyle, obesity is highly prevalent. Obesity is a chronic disease in the same sense as hypertension and atherosclerosis. The etiology or cause of obesity is an imbalance between the energy ingested in food and the energy expended. The excess energy is stored in fat cells that enlarge and/or increase in number. Capparis spinosais an economical species in Caparidaceae family with high medicinalvalues and play a pivotal role in traditional health care system. Studies have revealed the presence of phenolics, alkaloids, flavonoids (kaempferol, rutin, quercetin), glucosinolates (glucobrassicin, glucoiberin, glucocapparin, sinigrin), antioxidants, carotenoids, terpenoids and essential oils in different parts of the Capparisspinosa. The aqueous extracts of aerial parts of Capparisspinosa for it shep at oprotective effect against the paracetamol and carbonte trachloride induced hepatotoxicity in rats. Study revealed that acute toxicity and free radicle scavenging activity. Two groups , each containing 3 animals were randomly selected for the treatment with hydroalcoholic and ethanol extractof Capparisspinosa leaves. Results showed that hydroalcoholic & ethanolic extract of Capparisspinosa leaves on high fat induced obesity was reduced