Prophylactic Role of Curcuma Longa and Zingiber Officinale on Histological Changes of Testis and Kidney of Male Rats Treated with Hydrogen Peroxide

Abstract

       The present study aimed to investigate the prophylactic role of Zingiber officinale and Curcuma longa on histological changes of testis and kidney of male rats treated with hydrogen peroxide the male rats Rattus norvegicus divided in to four groups as follow the first group treated orally with 0.5 ml of physiological saline as a control group. The second group treated orally with 1 ml of hydrogen peroxide, the third group treated orally with 1ml hydrogen peroxide, and then treated orally with 0.5 ml of 200 mg/kg of Curcuma longa. The fourth group treated orally with 1 ml of hydrogen peroxide, and then treated orally with 0.5 ml of 200 mg/kg of Zingiber officinale. The duration of treatment was 30 days. Degenerative changes in various degrees were observed in microscopic examination of testis in animal group treated with hydrogen peroxide. In group treated with H2O2, testis showed inhibited spermatogenesis, testicular tubular degeneration and necrosis, obstruction of tubular lumen and lymphocytic infiltration ,the histological of kidney showed edematous glomerulus, necrosis ,congestion in blood vessel , degeneration in glumoular and  increased numbers of nuclei. In the third group there was a decreasing of testis damage and area of lesion, degeneration, necrosis  and, inflammatory infiltration compared to the second group, also in the section of the kidney we observed a few from inflammatory cells. A decreasing in degenerative changes was noticed in animals treated with hydrogen peroxide and 200 mg/kg of Zingiber officinale. The fourth treated group showed improve in histochange in testis . The section of testis was similar appearance with control group and in the section of the kidney a few of mononuclear cell.