Enhancement of Dissolution Rate and Bioavailability of Selected Class Ii Drugs by Using Solid Dispersion Technique

Abstract

The plausibility of defining the solid dispersions of celecoxib into tablet dose structures is assessed. All the tablets formed utilizing solid dispersions of celecoxib in super disintegrants gave fast and higher dissolution of celecoxib when contrasted with that of celecoxib plain tablets. The expanding request of dissolution rate of defined tablets with different transporters was Croscarmellose (CC)>Pregelatinised starch (PGS)> Primojel(PJ)> Crospovidone (CP). A similar request of execution was seen in both the arrangement of tablets formed utilizing superdisintegrants alone and in mix with PVP. An overlay increment in the dissolution rate of celecoxib was seen with tablets figured utilizing its solid dispersions in CC when contrasted with plain tablets .An overlap increment in the dissolution rate of celecoxib was seen with tablets formed utilizing its solid dispersions in consolidated transporters CC and PVP when contrasted with its plain tablets. A large portion of the new substance elements close about 40% are inadequately water solvent drugs. The solubility conduct of the drugs stay perhaps the most testing viewpoints in plan improvement and it is key determinant to its oral bioavailability and it is the rate restricting advance to retention of drugs from gastrointestinal parcel. This outcomes in significant items not arriving at the market or not accomplishing their maximum capacity. Solid dispersion has pulled in significant premium as a productive methods for improving the dissolution rate and bioavailability of hydrophobic drugs.