Evaluating the Effect of Different Types of Anesthesia on Intraoperative Blood Glucose Levels in Diabetics and Non-Diabetics Patients: A Systematic Review and Meta-Analysis

Abstract

Background and aim: the aim of present Systematic Review and Meta-Analysis was evaluate the effect of different types of anesthesia on intraoperative blood glucose levels of diabetes patients.

Method: From the electronic databases, PubMed, Cochrane Library, Embase, ISI have been used to perform a systematic literature over the last twenty years between February 2011 and January 2021. For Data extraction, two reviewers blind and independently extracted data from abstract and full text of studies that included.Prior to the screening, kappa statistics was carried out in order to verify the agreement level between the reviewers. The kappa values were higher than 0.80. Mean difference with 95% confidence interval (CI), fixed effect model and Invers-variance were calculated. Random effects were used to deal with potential heterogeneity and I² showed heterogeneity. I² values above 50% signified moderate-to-high heterogeneity. The Meta analysis have been evaluated with the statistical software Stata/MP v.16 (The fastest version of Stata).

Result:431 studies were selected to review the abstracts, finally ten studies were selected. Mean difference of post-operative blood glucose level between spinal and general anesthesia in non-diabetics patients was 22.12 (MD, 22.12 95% CI 21.79, 22.46; p=0.00), between epidural + general and general anesthesia in diabetics patients was -4.30 (MD, -4.30 95% CI -15.63, 7.03; p=0.46).

Conclusion:compared to different types of anesthesia in diabetic and non-diabetic populations, general anesthesia has better control in postoperative blood glucose levels.