Evaluation of Anti-nephrotoxic potential of leaf extracts of Tamilnadiaulginosa against Gentamicin-induced Nephrotoxicity

Abstract

Kidney being an essential organ performs various important functions in the body, one of which is the removal of waste products and controlling body’s fluid balance. Nephrotoxicity is one of the most common complications of kidney resulting mainly due to the exposure to the toxins which may be drug. Several efforts have been made to reduce nephrotoxicity and natural remedies are gaining great attention as they have lesser side effects as compared to the synthetic drugs.

Purpose.The current study is aimed to investigate anti-nephrotoxic activity of leaf extract of Tamilnadiaulginosa in rats.

Research material. The study comprises the results of ethanolic and aqueous extracts of T. Ulginosaat two different doses i.e. 200 mg/kg and 400 mg/kg against gentamicin-induced nephro-toxicity in rats.

Results. The ethanolic and aqueous leave extracts showed the presence of alkaloids, flavanoids, tannins etc. Two different doses (200 mg/kg and 400 mg/kg) of each extract were evaluated for the activity. Both the extracts showed significant activity at selected doses while aqueous extract exhibited better activity as compared to other treatment. Thus the ethanolic and aqueous extracts of T. ulginosacan be considered as promising drugs in the management of drug induced nephrotoxicity.

Conclusion. The treatment with plant’s leaf extracts showed significant efficacy and proves the traditional use of the plant which may be due to the active phytoconstituents present probably by reducing oxidative stress induced by gentamycin.