Surface Characterization, Cytotoxicity, and Antimicrobial Activities of a Denture Base Resin Coated with Cnidium Officinale Extract

Abstract

This study was aimed at investigating the surface characterization, cytotoxicity, and antimicrobial activities of a denture base resin coated with Cnidium officinale extract. 

Cnidium officinale extracts were prepared at different concentrations, and the surface characterizations such as wettability, microhardness, and color changeof surfacewere measured. To evaluate the in vitro cytotoxicity, MTT assay was carried out in accordance with ISO 10993-5 standards. For the microbial analysis, two major oral microbes; Streptococcus mutans and Candida albicans were used in this study. All measurement data were analyzed with one-way ANOVA and Tukeys statistical test (p=0.05).

There were no significant differences in the surface characterizations and cell viability between the experiment group and the control group (p>0.05). However, there were significant differences in the antimicrobial activities between the experimental group and control group to Streptococcus mutans and Candida albicans (p<0.05). Denture base resins coated with Cnidiumofficinale extracts can function as antimicrobial denture base resins in dentistry.