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This study purposed to investigate the infection disaster risk and response system against the spread of COVID-19.For COVID-19 outbreak status, the data on daily briefings regarding Coronavirus Disease-19, Republic of Korea," as disclosed by MOHW and KCDC, were coded. The research on COVID-19 covered the period from January 20 to May 15, 2020. The total numberofCOVID-19 confirmed cases is 11,018.The death was 260. The data were using SPSS for Windows 20.0 Version.Between January 20, 2020, when COVID-19 broke out, and May 15, 2020, 11,018 cases were confirmed, 9,821 were released from quarantine, and 260 were dead. No more than 2.35% of all the confirmed cases (260/11,018) were dead by May 15, 2020. 89.1% were released from quarantine by May 15, demonstrating a good public health system.Despite community infection, the mortality rate was generally low. This might have resulted from the K-Quarantine, which is characterized by the low mortality rate with journey disclosure for the confirmed cases, quick quarantine, the efficient examination system using Drive-Thru and Walking-Thru, and the social distancing policy. Therefore, building an efficient infection disaster response system can reduce the risk of any sudden infection disaster occurrence.