Cellular Energy, Nutrients and Metabolic Factors Affecting Immune System in Multiple Sclerosis

Abstract

Multiple sclerosis (MS) is an auto immune neurodegenerative disease of the central nervous system (CNS) which mostly affects 20 to 50-year-old people. The prevalence of MS is higher in women in comparison with men similar to other autoimmune diseases. Its prevalence is estimated to be 22 prevalent cases per 100,000 in 2019. Numerous studies investigated the role of immune system and immune cells in the pathophysiology of MS and the course of its progression. Current evidence points to the relation of certain metabolites and their effect on immune system and subsequently on MS itself. From mitochondrial respiratory chain components to vitamins and other nutrients, all affect immune responses in MS. This mini-review was conducted on recent studies through literature review of PubMed library.