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The purpose of present study was to confirm the antimicrobial efficacy against Streptococcus mutans and Candida albicans, surface characteristics, and biocompatibility of a denture relining material coated with Glycyrrhiza uralensis extract.A polymerized denture relining disk was coated with Glycyrrhiza uralensis extract (200, 400, and 600 g/ml). Coated disk specimens incubated with each microbial were evaluated based on spectrophotometric growth inhibitory assay. The contact angle, microhardness, and color change of coated specimens were measured. Coated specimen was soaked in distilled water for one day. Extracts were analyzed using a UV/VIS spectrometer to determine the amount of polyphenol content. Biocompatibility of the coated specimens was assessed with MTT assay. Obtained values were analyzed with one-way ANOVA and Tukeys statistical test.Glycyrrhiza uralensis coated specimen showed a significant growth inhibitory effect on each microbial, demonstrating antimicrobial efficacy. Water contact angle, microhardness, and deltaE* values did not show significant differences between the groups. When the content of Glycyrrhiza uralensis extract was increased, the level of polyphenol was significantly increased. None of the experimental groups had cytotoxicity.A coating material containing Glycyrrhiza uralensis extract is a promising candidate for an antimicrobial dental resin. The newly developed coating resin will not degrade the surface or the biocompatibility properties of the denture relining material.