Comparative Efficacy of Oral Metaprolol Vs Oral Clonidine as Premedicants for Hypotensive Anesthesia for Patients Undergoingfunctional Endoscopic Sinus Surgery under General Anesthesia

Abstract

This prospective randomized study aimed to  analyze the effect of metoprolol and clonidine premedication on the peri-operative characteristics of patients undergoing FESS procedure under GA and induced hypotensive anaesthetic technique.The Present study includes the Clonidine and metoprolol premedication produces predictable and superior hemodynamics during peri- operative period, with metoprolol being superior to clonidine and Clonidine and metoprolol premedication decreases the intra-operative requirement of vasodilators like NTG.This study focuses on Clonidine and metoprolol premedication decreases the requirement of inhalational  anaesthetics  like isoflurane to maintain hemodynamic control and Clonidine premedication produces increased incidences of undesirable alterations in BP, which extended into the early post-op period, but could be easily treated.It  produces better sedation and anxiolysis pre- op and reduces the requirement of post-op analgesia as noted by delayed TAR times which also inturn reduces the incidence of post-anaesthetic shivering and leads to produces lesser perturbations  in  HR and BP in response to intubation in  Metoprolol.