Effecting of Hemodialysis Progression on Thyroid Hormones and Complete Blood Count for Iraqi Chronic renal failure Patients

Abstract

Background: Chronic renal failure is one of the most reasons of death globally today.Numbers of persons with this disease is rising rapidly. Advancement of disease is associated with several complications, as well as thyroid dysfunction and  Blood disorders.

Methods: Case-control study was conducted among sixty Iraqi people samples. Thirty healthy people and other thirty chronic renal failure people. Blood samples (5 ml) were collected to evaluate T3, T4, TSH,Hemoglobin, RBCs count, WBCs count, platelets count, MCV, PCV, MCH and  MCHC. (LSD), (ANOVA) and correlation of coefficients were used in statistical analysis at p ≤ 0.05.

Results: Significant decrease in the levels of T3 and T4hormones, while there is significant increase in the level of TSH hormone in patients undergoing hemodialysis by progression of hemodialysis period compared to the control group. Significant decrease in the levels of Hemoglobin, RBCs count, PCV, while there is significant increase in the WBCs count. Insignificant differences in platelets count, MCV, MCH and  MCHC. Correlation of coefficient analysis shows a positive and negative correlation between the most studied variables

Conclusions: Thyroid dysfunction and blood disorders are common in  Iraqi Chronic renal failure patients. progression of hemodialysis period have significant effect on all of ( T3,T4,TSH, Hemoglobin, RBCs count, WBCs count and PCV) and insignificant effect on all of (Platelets count, MCV, MCH and MCHC). Chronic renal failure is main cause of Thyroid dysfunction and anemia diseases.