Study the Relationship between Ca Ions Level and Osteoporosis in Thyroid Diseases Patients

Abstract

D3 is a steroid (fat soluble) vitamin, produced in the skin. D3 receptors found in most tissues in the body and has many roles especially in the regulation of calcium and phosphorous homeostasis. Recently, many research suggest that deficiency in vitamin D3 has a role in many diseases with autoimmune disorders, many cancers, heart diseases and death. Lowering   in vitamin D3 levels also associated with autoimmune thyroid disease (AITD). Our study aimed to find the correlation between deficiency in vitamin D3 and osteoporosis, study a relationship of D3 deficiency and thyroid disease and to find the effect of thyroid disease on osteoporosis. The experimental groups used consist of  70 patients age ranged from (18-84) years old, they are divided into three groups: group (1): (group with normal D3), group (2): patients with D3 deficiency without osteoporosis and group (3): patients with D3 deficiency and osteoporosis. Serum Vit.D3,Ca,T3,T4 and TSH were measured and osteoporosis was diagnosed by bone densitometry method.Our results showed that the Mean ± SE values of T4,Ca and D3 were lower in patients suffering from D3 deficiency with osteoporosis than that of control group and patients with D3 deficiency without osteoporosis (P≤0.01), a significant positive correlation coefficient of T4 with Ca and vit.D3 (P≤0.01), but a no significant positive correlation coefficient of T3 with TSH and vit. D3, no significant  negative correlation coefficient of T3 with Ca. We concluded that Iraqi patients with hypothyroidism suffering from deficiency in vitamin D3 and Ca that in turn leads to osteoporosis. Vitamin D and Ca levels screening was recommended to all Iraqi patients with hypothyroidism to avoid osteoporosis if the deficiency continued.