Nephropathy Effects of 2,3,7,8-Tetrachlorodibenzo-P-Dioxin (TCDD) Toxicity In Ova Injected Chicken

Abstract

             Eggs are importance in human feeding, it is inexpensive and complex source of food with highly biological value, The aims of this study to investigate the evaluation toxicity of pollution of biological tissue characterized by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) toxicity in kidney chickens.Chiken eggs are attractive bioindicater of pollution. Sixty chiken eggs fertile suplier from local market of Baghdad province from Alzafaranya city, these eggs were divided equally and randomly into three equal group: 1^st group injected into aircell with 0.2 mg/ kg corn oil at day 4 , 2^nd group injected in aircell at day 4 with 0.1mg/ kg TCDD dissolve in corn oil, 3^rd group group injected in aircell at day 4  with 0.2mg/ kg TCDD dissolve in corn oil. The eggs incubated for 21 days. Biochemical assay (Creatinine and Urea) concentration and pathological examination were observed  on chicken at days 15 and 30. Biochemical assay of kidney function found significant increased P<0.05 in serum urea concentration & creatinine concentration at days 15 & 30, with highly increased in dose 0.2 mg/ kg at day 30. Pathological lesion characterized by chest and abdominal edema, hydronephrosis with severe tubular and glomeruli damage, in addition of destruction with extensive hemorrhage & lymphocytic infiltration.