Study of Single Dose versus Multiple Dose Antibiotic Prophylaxis in Electiveceasarean Section

Abstract

            To compare the effectiveness of single dose antibiotic prophylaxis and routine multiple dose antibiotic prophylaxis, with regards to postoperative infective complications, in patients who are undergoing elective caesarean section. Reduction in the number of doses of antibiotics  will reduce the chances of emergence of  drug resistant strain  of bacteria and also  prevent  unnecessary drug  exposure to vast majority of patients. The single dose antibiotic is safe, effective, convenient and economical. And it is better in case of low risk and routine cases of caesarean section.In this era of rising antibiotic resistance, lesser usage of antibiotics has become the need of the hour and this study has given positive reinforcement towards the same direction. It is concluded from this study that the single dose prophylactic antibiotic is equally efficacious as  multiple dose prophylaxis in elective uncomplicated caesarean section. There was no statistically significant difference noted between the  two groups when compared in terms of febrile morbidity, wound induration, serous wound discharge,  purulent  wound  discharge, wound gaping, uterine involution, UTI or abnormal vaginal discharge.