Effect of Osteopontin and Other Biochemical Markers on Iraqi Women with Osteoporosis

Abstract

Osteoporosis is a common problem that affects the bones, causing decreasing the mineral density in them (BMD), so the bones become weak and easy to break. Women are more susceptible to osteoporosis than men. The purpose of this current study is to know the effect of decreasing or increasing serum levels of osteopontin (OPN) and some biochemical markers of Iraqi women. In this study, 40 samples are collected from women over the age of forty and have osteoporosis. Different biochemical markers are measured such as vitamin D3, calcium ( ,Phosphorus ( ),uric acid (U.A, total cholesterol (TC), triglycerides (TG), alkaline phosphatase (ALP), high-Density Lipoprotein (HDL), the results of measurements are compared with 40 samples of healthy women. After examining the results, it was found that the levels of osteopontin, total cholesterol, triglycerides, and alkaline phosphatase are high compared with the control group with a significant difference (P≤0.001). And the result shows low levels of (high-Density Lipoprotein, vitamin D3, calcium, Phosphorus) of serum comparing the healthy group with a significant difference (P≤0.001). High levels osteopontin in the serum of and low levels of some biochemical markers such as (vitamin D3, calcium,Phosphorus and high-Density Lipoprotein) can be used in the diagnosis of osteoporosis.