First and Second Line of Treatment for Tuberculosis: A Mathematical Model with Drug Resistance.

Abstract

This study proposed a mathematical model of tuberculosis with drug resistance to a firstand second line of treatment.The basic reproduction number for the model using next generation method is obtained.The equilibrium point of the model was investigated and also found the global stability of the disease freeequilibrium and endemic equilibrium for the model. This study shows the effect of resistance rate of the first and second line of treatment to the infected and resistant population. If basic reproduction number is less than one, the disease free equilibrium is globally asymptotically stable and if basic reproduction number is greater than one, then the endemic equilibrium is a globally asymptotically stable.