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Hepatic diseases are a major concern worldwide. Gold nanoparticles (GNPs) are a tremendous scientific achievement of nanotechnology and are used in various fields of medicine. In this study, (24) healthy Albino rats have been divided into 4 groups, 6 animals for each. The control animals included rats without treatment, while the GNPs group rats received 1100 g/kg of GNPs. In the GNPs +TC group, rats were co-administered with a combination of GNPs at a 1100 g/kg dose with Tinospora cordifolia at a 400 mg/kg dose. The TC group animals were treated with 400 mg/kg of T. cordifolia. The levels of serum hepatic parameters including Alanine amino transferase (ALT), Aspartate amino transferase (AST) and Alkaline phosphatase (ALP) have been estimated to detect liver function disorders. Rats treated with GNPs showed significant increase (P<0.05) in plasma enzyme levels in comparison to control group. Then, co-administration of T. cordifolia along with GNPs exerted a significant recovery effect in liver function disorders. Thus, these results demonstrated that T. cordifolia has shown a defensive impact against GNPs induced biochemical changes in liver function of rats.