Protease Activated Drug Development-A Review

Abstract

            Protease is referred to as a  group of enzymes whose catalytic function is to hydrolyze peptide bonds of proteins, they are also called proteolytic enzymes or proteinases.The action of proteases was thought to be restricted to digestive, extracellular modelling and tissue reshaping purposes, mainly by proteolytic activities throughout Homeostasis and Interstitial molecules.  development also in aberrant maladaptive circumstances, during disease pathogenesis. Proteases can also be involved in various aspects of human biology. Proteases, for example, digest food proteins in the small intestine to  allow amino acid absorption.Other processes mediated by proteases include immune function,  blood coagulation, bone formation, maturation of prohormones, programmed cell death, and the recycling of cellular proteins that are no longer needed.Proteases are not restricted to only digestive and tissue reshaping purposes, but are also essential as essential factors for physiological immune responses to the diseases. Proteases are essential. This activation may be directed by the destruction of indirect pathogens or phagolysosomes, through activating checks pattern recognition receivers such as over head receptors.. Unfortunately, excess production of proteases that can also lead to excess tissue inflammation and damage maladaptive host responses. Protease-activated prodrugs can be exploited or destroyed to improve drug delivery. This review was prepared with an intention to discuss the use of proteases in drug development.