Antibacterial Effect of Spirulina platensis Extracts on the Viability of Bacterial Species Isolated form Acne Patients in Baghdad

Abstract

Considered as Cyanobacteria are very rich source of secondary metabolites that are biologically active metabolites for anticancer activities, antifungal, antibacterial, antiviral. Current study was to determine the antibacterial Isolated from patients with acne.Efficacy of the Hexane and Methanol crude extracts of cyanobacterium Spirulina platensis was determined. Antibacterial activity (In vitro) was estimated by agar disc diffusion assay mod against twelve pathogenic bacteria in which four were Gram-positive and eight of them were Gram-negative bacteria.All bacteria tested with S. platensis extracts found varying degrees of inhibitory activity. The zone of inhibition for   different extracts was divers from solvent to solvent. One g of dried S. platensis suspended in 100 μl of distill water to prepare the concentration of (25, 50,100)μl  was put in the well.S. platensis was exhibited with maximum inhibition zones (16 and 13) mm in the hexane extract against Aerococcus spp. At 100 and 50 μl respectively, antibacterial activity was found high 13 and 10mm in methanol extract againstAerococcus spp., Enterococcus at 25μl under investigation. Also hexane extractshowed no effect at concentration 25 for all bacterial isolates.GC-MS analysis of hexane and methanol extracts of S. platensis were showed differentactive compounds like, Hexadecene, Heptadecane, Octadecene, 2-Bromopropionic Acid, Methyl-1-Docosene, Benzenedicarboxylic Acid, and Tetradecanol which they are very important as antibacterial agents .