Determination of Resistin, Apelin, Visfatin and Lipid Profile Levels Incolon Cancer Patients

Abstract

According to a report by the National Cancer Institute, colon cancer is still one of the most common leading causes of cancer death worldwide and the second  cause of mortality from cancer. Colon cancer is often recognized very late for successful therapy.. It is linked to various reasons such as socioeconomic status,  dramatic changes in  the dietary habits, chemical preservatives, the presence of refrigeration and the environmental changes.  Our study aimed to estimate resistin, apelin and visfatin  concentrations and lipid profiles levels in colon cancer  patients.. The study group included (74) patients with colon cancer and a control group of (60) healthy subjects. The biochemical assays include resistin,apelin, visfatin, total cholesterol (T-Cho), triacylglycerol (TAG),low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C) and very low density lipoprotein cholesterol(VLDL-C). The results showed  significant increase at (P≤0.0001) in serum resistin,apelin,Visfatin, T-Cho, TAG, LDL-C and VLDL-C in the  colonic cancer patients compared with  the control group, while blood serum HDL-C  showed a significant decrease (P≤0.05) in  colonic cancer patients when compared with  the control group. The patients also were divided into four groups according to colon cancer stage, the results revealed no any significant differences (p > 0.05) between the stages in the concentrations of parameters under study except there was significant differences (p<0.05) in concentration of resistin when comparing stage 3 versus stage 4. The aim of the study was to find the relation between hormones(Resistin,Apelin,Visfatin) and lipid profile  in patients with colon cancer.