Interferon Gamma and its Correlations with IGE and NLRP3 in Eosinophilic and Non-Eosinophilic Asthma

Abstract

Asthma is a chronic inflammation of the lower respiratory tract with a range of symptoms including coughing, whistling and shortness of breath. The aim of the study is to investigate the correlation of interferon gamma (INFγ) and its correlation with the levels of IgE and NLRP3 in asthma phenotypes of patients in Basrah. The study included 112 particpants (69 AS patients and 43 healthy controls). Complete Blood Count (CBC) was performed for asthma’s phenotype discrimination, and the level of INFγ was measured using enzyme linked immunosorbent assay (ELISA). Additionally, with the use of data from previous study (unpublished data) the correlations between INFγ, IgE and NLRP3 were investigated in asthma phenotypes using Pearson’s correlation. The results of the current study showed that the majority of asthma patients were non-eosinophilic asthma, moreover, no obvious differences in the level of INFγ among the study groups. Furthermore, positive and significant correlation were found between INFγ and NLRP3 in non-eosinophilic asthma. In conclusion, the non-eosinophilic asthma was predominant among patients living in Basrah. In addition, the positive and significant correlation between INFγ and NLRP3 suggest a role of these two parameters in non-eosinophilic asthma.