Formulation Development and Evaluation of Niosomes Containing Extract of Tecoma stans (L.) Juss. Ex Kunth

Abstract

Niosomes are becoming increasingly relevant in medication administration because they can lower toxicity and alter pharmacokinetics and bioavailability. Topically applied niosomes can improve drug residence duration in the stratum corneum and epidermis while decreasing systemic absorption. It can function as a drug reservoir, and changing the vesicular compositions or surface features can alter the drug release rate and affinity for the target site. Ketoconazole is an imidazole derivative with a broad spectrum of action that can be used to treat both superficial and systemic fungal infections. Tecoma stans (L.) Juss. Ex Kunth. Commonly known as Piliya (H), Yellow trumpet busy, Yello bell (E) belongs to family Bignoniaceae is an evergreen ornamental garden and street plant present in wild state. Almost every part of the plant is used medicinally for the treatment of various diseases. The flowers of the plant are used in the treatment of fungal infection, inflammations, stomach pain, diabetes and many others disorders of human being. In the present work ethanolic extract of flowers of plant was taken in consideration to formulate Niosomes and was further evaluated. The results indicate that most promising formulation was F8, which contained Tween 40 as surfactant at ratio of 2:1 with cholesterol.