Evaluation of Anxiolytic Medication in Animal Models

Abstract

Anxiety disorders are among the most prevalent and debilitating forms of mental illness, not only in the United States but globally. These clinical data are undoubtedly inconclusive, but if anxious humans respond more inconsistently to buspirone than to benzodiazepine anxiolytics, then buspirone may be superior. A drug may have very reliable impacts in an animal model of anxiety, but only if it also has reliable antianxiety impacts in people. The clinical effectiveness of antidepressant medications in treating anxiety disorders is much more convincing, but there are still differences in effectiveness. This study indicates that buspirone (0.05-1 mg/kg) did not significantly alter the suppressed response rates. Smaller doses of buspirone (0.03-0.5 mg/kg) did not increase the rate of suppressed responding, whereas higher doses (0.5 mg/kg) had the opposite effect. The doses of diazepam (0.2-1 mg/kg) found to be associated with enhanced response. Even after 12 days of daily dosing, buspirone (0.05-1 mg/kg) had significant effect. The findings indicate that buspirone has distinct effects on schedule-controlled behaviour compared to conventional anxiolytics. In this literature we discuss about the difference between buspirone and benzodiazepine anxiolytic and antidepressant effect using animal model.