Genetic Polymorphism of Kazakhstan Meat Breeds of Cattle in Relation to Resistance to Brucellosis

Abstract

The authors investigated polymorphism of the BoLA-DRB3 gene in connection with the resistance or sensitivity to brucellosis of two meat breeds – Auliekol and Kazakh white-headed breeds, using PCR- RFLP. In healthy Auliekol group of 84 cows 24 alleles were detected, and in a group of 74 cows with brucellosis, 22 alleles were shown. The results of Auliekol breed showed the presence of alleles *3, *4, *19, *21, mostly common in healthy cows, and cows - brucell carriers had frequent alleles *7, *10, *18. In Kazakh white-headed cows (73 individuals) 23 alleles were detected in healthy and 21 alleles in patients. Alleles *3, *8, *21 significantly predominate in healthy cows, while alleles *7, *11, *16 are typical for cows with brucellosis. The authors first discovered the presence of genetic resistance to brucellosis in two meat breeds of Kazakhstan by the BoLA-DRB3 gene (*3 and *21) and genetic sensitivity to brucellosis (*7).