Possibilities of Ovarian Endometriosis Neoplastic Transformation

Abstract

Objective: to analyze the signs of neoplastic transformation of the epithelium of ovarian endometriosis foci.

Materials and methods: We have analyzed 78 and 35 cases of ovarian endometriosis, using the histological and immunohistochemical methods respectively, and 8 cases of adenocarcinoma. The analysis took into account antibodies to Ki-67, Всl-2, p53 and hepatocyte nuclear factor-1beta (HNF-1β).

Results: In the epithelium of endometrioid cysts walls, we determined syncytial papillary changes (39.7%), hobnail cell metaplasia (15.4%), and epithelium atypia (41.0%) with the expression of Ki-67 and Bcl-2 fluctuating from low to relatively high values and with the expression of p53 with a tendency to increase. HNF-1β expression in the foci without atypia was detected in 56.3% of cases, and in the foci with atypia - in 94.7% of cases; it was found only in clear cell adenocarcinomas.

Conclusion: HNF-1β hyperexpression suggests the adaptive nature and histogenetic connection of ovarian endometriosis with clear cell ovarian tumors.