Evaluation of Biochemical Parameters on Tobacco Chewers in Different Age Related Groups

Abstract

ABSTRACT

Background: Tobacco chewing and alcohol abuse are accepted as ‘two-hit’ hypothesis of cardiac arrest and liver disease. However, there are few research articles on identifying genes which connect lipid and glucose metabolism by liver markers enzymes.

Objectives:  To diagnoses of alcoholic liver disease were made based on the combination of history of tobacco chewing, alcohol abuse and increased levels of liver enzymes, in the absence of other causes for liver disease.

Methods: To analyse the human serum marker enzymes of alcoholic fatty liver disease was established by different habit human samples estimate the expression of liver marker enzymes were determined using the automatic biochemical analyser.

Results Blood  glucose  levels  were  significantly  increased  and  may  be  due  to  hyperglycemia  in  blood  system. Protein  levels  were  moderately  decreased,  indicating  rate  of  protein  catabolism  in  tobacco  chewers. Urea  levels  were  increased  due  to  increase  rate  of  protein  catabolism  this  inturn  lead  to  increased  excretion  of  urinary  nitrogen. Level  of  creatinine  are  increased  may  be  due  to  the  reduction  of  muscle  mass  during  aging. Elevated levels of uric acid were due to hyperuricemia. Cholesterol  levels  were  significantly  enhanced  whereas  HDL  cholesterol  was  significantly  decreased  in  tobacco  chewers. The  increasing  serum  cholesterol  may  be  due  to  increased  LDL  and  VLDL.

Conclusions: Chewing tobacco  could  result  in  significance  greater  deleterious  cardiovascular  effects  due  to  cholesterol,  glucose,  LDL  and  low  HDL  cholesterol  in  tobacco  user  as  compared  to  tobacco  non – user.