Formulation and Evaluation of Polyherbal Gel Containing Plant Extracts

Abstract

 Solanum xanthocarpum, Trigonella foenum greacum and Sesbania grandiflora  herbs are highly used by the rural and tribal people in curing various disorders. The aim of the current investigation is to formulation and evaluation of polyherbal gel. S. xanthocarpum, Trigonella foenum greacum and Sesbania grandiflora  hydrogel were prepared, optimized and characterized for spreadibility, consistency Ph, viscosity ,stability  and in-vitro release study.

The result showed that Formulation FE₄ had good values of spreadability, viscosity, pH, drug content and during the accelerated stability studies the appearance was clear and no significant variation in spreadability, pH and drug content was observed. Hence Hydroalcohalic gel FH was formulated from hydrogel FE₄ formulation and its physiochemical study was found to be good. Percentage drug release of Hydroalcohalic gel FE₄ and FH formulation containing combination of plants extract Trigonella foenum greacum , Sesbania grandiflora  and S. xanthocarpum extract was observed to be 24.24% and 28.37% (at 30 min.) and 56.71 % & 62.21% (at 180 min.) respectively at 234 nm. While in 206 nm it was observed to be 29.13% and 31.41% (at 30 min.) and 61.51 % & 69.32% (at 180 min.) respectively.