A Role of Antioxidants in Cervical Cancer

Abstract

Non-communicable diseases (NCDs) will account for 70% of the mortality globally in future.Cancer is the second most common cause of morbidity and mortality in both developed and developing countries. Substantial epidemiological data on populations indicate an association between many human cancers and lifestyle/diet.Cervical cancer remains a great problem for woman health, as it is the second deadly cancer of females worldwide. Oxidative stress is defined as an imbalance between production of free radicals and reactive metabolites, supposed oxidants or reactive oxygen species (ROS), and their elimination by protective mechanisms, referred to as antioxidants.ROS are products of a normal cellular metabolism and play vital roles in the stimulation of signaling pathways in plant and animal cells in response to changes in intra- and extracellular environmental conditions. Imperfections in the antioxidant enzyme systems are stated to play chiefpart behind this antioxidant deficiency, which is responsible for the production of reactive oxygen species and ultimately, DNA damage in cervical cells. The key of the presentstudy was evaluating the enzymatic and non-enzymatic antioxidants in cervical cancer patients in serum and cervical tissue.