Association Of Serum Uric Acid Level in Diabetic, Prediabetes and Non-Diabetic Individuals: A Comparative Cross Section Study

Abstract

Aim: To assess the association of serum uric acid level in diabetic, prediabetes and non-diabetic individuals

Study Design: Cross section study

Place and duration: This study was conducted in People's University of Medical Health Science For women Nawabshah Pakistan. From January 2019 to January 2020.

Methodology: Samples of fasting blood sugar, serum uric acid and some other variables of 119 subjects were collected. Total 80 (67.22%) of them were male and 39 (32.78%) were female. Prediabetes was interpreted as fasting blood sugar from 100 to 125 mg/dl. Diabetes was defined as fasting blood sugar equal to or more than 126 mg/dl. Multinomial logistic regression analysis was used for the evaluation of the association between diabetes and serum uric acid.

Results: The lower mean value of serum uric acid for prediabetes patients was 331.8±100.5 µmol/L, the value for the diabetic patients was 295±90.8 µmol/L and it is 372±112.8 µmol/L for nondiabetic individuals (p<0.001). Body Mass Index, triglyceride and total cholesterol levels are directly related to the level of serum uric acid, whereas, the level of fasting blood sugar is negatively associated with it. In all the groups, diabetes prevalence reduces with an elevation in concentration of serum uric acid. Hence, there is an inverse relationship between diabetes and serum uric acid according to regression analysis.

Conclusion: There is a negative correlation between serum uric acid and diabetes. Serum uric acid was seen raised in nondiabetic individuals as compared to those who were either diabetic or prediabetic.