The Effect of Tranexamic Acid on Blood Loss and Hospital‐Stay after Knee Replacement Surgery

Abstract

A widely used effective treatment for last stage osteoarthritis and other knee diseases to relieve pain and to have improved quality of life. While the benefit outweighs other methods there are also some risks involved including bloodloss   thromboembolic  events,  infection  and  sometimes  the  need  for  additional  surgical  procedures.  Tranexamic  acid  (TXA)  is  very effective  in  reducing    hemorrhage  after  this  major  surgical  operation.

Objectives:To analyze and determine the effect of Tranexamicd acid on blood loss and hospital stay after Knee replacement surgery

Methods & Materials:Total 104 TKA patients were enrolled in this study. The tranexamic acid group had of 52 patients who received an intravenous injection  IVof tranexamic acid. The control group included 52 patients on those placebo injection was administered. The comparison factors were the amounts of drainage, postoperative hemoglobin, and transfusion between both groups.

Results:The results showed the lower mean amount of blood drainage in the teranexamic acid group than in the control group i.e(581.6±356mL) versus (887±376.5mL) and p value was found to be p=0.002There was observed to be reduced transfusion rate in the tranexamic acid group (42.3%) in comparison with the  control group (63.5%).  Postoperatively at 24 hours the levels of  hemoglobin were observed to be  higher in the tranexamic acid group than in the control group.

Conclusions:Decrease in the total blood loss and transfusion was found by the use of IV(intravenous) injection of tranexamic acid.